Lipoprotein Lipase Activator, NO-1886

  • Lipoprotein Lipase Activator, NO-1886
Catalog No.: 9780

An inducer of lipoprotein lipase mRNA.

 

 

Chemical Name: Diethyl {4-[(4-bromo-2-cyanophenyl)carbamoyl]benzyl}phosphonate

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Biological Activity:
Lipoprotein Lipase Activator is a cell-permeable benzylphosphonate derivative that selectively induces lipoprotein lipase (LPL) mRNA and protein levels, but does not exhibit PPARα or PPARγ agonistic activities. Lipoprotein Lipase Activator lowers serum lipid levels and plasma triglycerides with concomitant elevation in high-density lipoprotein cholesterol (HDL-C) in animal models. Lipoprotein Lipase Activator also induces fatty acid oxidation related enzymes, lowers free fatty acids (FFA), and minimizes fat accumulation. Also reported to suppress the plasma levels of TNF-a and COX-2 and displays anti-tumor properties.
Technical Data:
M.W. 451.3
Formula: C19H20BrN2O4
Solubility: Soluble in DMSO (≥20 mg/ml).
Storage: Store at -4 C
CAS No: 133208-93-2
References:
Niho, N., et al. 2005. Proc, Natl. Acad. Sci. USA 102, 2970. Yin, W., et al. 2004. Pharmacol. Res. 49, 199. Doi, M., et al. 2003. Metabolism 52, 1547. Kusunoki, M., et al. 2000. Diabetologia 43, 875. Tsutsmi, K., et al. 1993. J. Clin. Invest. 92, 411.

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Tags: Lipoprotein Lipase Activator, NO-1886, Enzyme activators, activators, lipase activator, 133208-93-2

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