JIB 04

  • JIB 04
Catalog No.: 6887

Pan Jumonji histone demethylase inhibitor (IC50 values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). Exhibits negligible activity at PHD2 and TET1. Selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. Prolongs survival in a mouse model of breast cancer.

Chemical Name: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine

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Technical Data:
M.W. 308.76
Formula: C17H13ClN4
Solubility: Soluble to 100 mM in DMSO and to 50 mM in 1eq. HCl
Purity: >99 %
Storage: Store at +4°C
CAS No: 199596-05-9

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