Vardenafil HCl Trihydrate

  • Vardenafil HCl Trihydrate
Catalog No.: 3196

Vardenafil HCl Trihydrate is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

Chemical Name:
2-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one hydrochloride trihydrate

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Biological Activity:
Vardenafil Hydrochloride Trihydrate (Vivanza) is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively. Vardenafil’s indications and contra-indications are the same as with other PDE5 inhibitors; it is closely related in function to sildenafil citrate (Viagra) and tadalafil (Cialis). Structurally, the difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom’s position and the change of sildenafil’s piperazine ring methyl group to an ethyl group. [1] Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction.
Technical Data:
M.W. 579.11
Formula: C23H32N6O4S.HCl.3H2O
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 224785-90-4

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Tags: Inhibitors, Metabolism, Phospholipase (e.g. PLA), Vardenafil HCl Trihydrate, 224785-90-4

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