TX-1918

  • TX-1918
Catalog No.: 9786

A potent inhibitor for eEF2K

 

 

Chemical Name: 2-((3,5-dimethyl-4-hydroxyphenyl)-methylene)-4-cyclopentene-1,3-dione

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Biological Activity:
TX-1918 may be useful as a therapeutic agent for cancer treatment in animal models. A cell-permeable arylidene-cyclopentenedione derived tyrphostin that acts as a potent inhibitor for eukaryotic elongation factor-2 kinase (eEF2K, IC50 = 440 nM). At higher concentrations, TX-1918 has been shown to inhibit other kinases, including proto-oncogene tyrosine-protein kinase Src (c-SRC, IC50 = 4.4 μM), protein kinase A and C (PKA and PKC, IC50 = 44 μM for each), and epidermal growth factor receptor kinase (EGFR-K, IC50 = 440 μM).
Technical Data:
M.W. 228.2
Formula: C14H12O3
Solubility: Soluble in DMSO (10 mg/ml).
Storage: Store at 4° C
CAS No: 503473-32-3
References:
Hori, Hitoshi., et al., 2002. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorganic & medicinal chemistry. 10(10): 3257-65. PMID: 12150871

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Tags: eukaryotic elongation factor-2 kinase, eEF2K, EGFR-K, PKA, PKC, Src, c-SRC, HepG2, 503473-32-3

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