PKR Inihibitor

  • PKR Inihibitor
Catalog No.: 9781

An RNA-dependent protein kinase inhibitor, PKR inhibitor may protect cells against ER stress induced cell damage.



Chemical Name: 8-(1H-Imidazol-5-ylmethylidene)-6,8-dihydro-7H-[1,3]thiazolo[5,4-e]indol-7-one

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Biological Activity:
PKR Inhibitor is an imidazolo-oxindole derivative that has been shown to inhibit RNA-induced PKR autophosphorylation and rescue PKR-dependent translation block. The alpha subunit of the eukaryotic initiation factor 2 is phosphorylated by the PKR, which is an interferon-induced serine/threonine protein. PKR influences cytokine gene expression stimulated by the latent membrane protein 1 (LMP) in Epstein-Barr virus. Research shows that PKR inhibitor inhibits the activities of caspase-3 and caspase-8 and prevents increase in pT(451)-PKR and pS(194)-FADD levels in SH-SY5Y nuclei
Technical Data:
M.W. 268.3
Formula: C13H8N4OS
Solubility: Soluble in DMSO (12 mg/ml).
Storage: Store at 4° C
CAS No: 608512-97-6
1. Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun. 308: 50-57. PMID: 12890478 2. Shimazawa, M., et al. 2006. Neurosci. Lett. 409: 192-195. PMID: 17055645 3. Lin, S.S., et al. 2010. Cytokine. 50: 210-219. PMID: 20171114 4. Couturier, J., et al. 2010. J. Biol. Chem. 285: 1272-1282. PMID: 19889624

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Tags: An RNA-dependent protein kinase inhibitor, PKR inhibitor, cell damage, 608512-97-6

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