Trametinib

  • Trametinib
Catalog No.: 3203

Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Phase 3.

Chemical Name:
N-(3-(3-cyclopropyl-5-(2-fluoro-4-iodophenylamino)-6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide

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$616.00 In Stock
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Biological Activity:
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2. Phase 3.
Technical Data:
M.W. 615.39
Formula: C26H23FIN5O4
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 871700-17-3
References:
Yamaguchi T, et al. Int J Oncol, 2011, 39(1), 23-31. Yamaguchi T, et al. Inflamm Res, 2012, 61(5), 445-454. Greger JG, et al. Mol Cancer Ther, 2012, 11(4), 909-920. Khalili JS, et al. Clin Cancer Res, 2012, 18(16), 4345-4355.

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Tags: Inhibitors, MAPK, MEK, Trametinib, 871700-17-3

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