Amuvatinib

  • Amuvatinib
Catalog No.: 3026

Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-KitPDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Phase 2.

Chemical Name:N-(1,3-Benzodioxol-5-ylmethyl)-4-benzofuro[3,2-d]pyrimidin-4-yl-1-piperazinecarbothioamide

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Biological Activity:
Amuvatinib (MP-470) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Phase 2.
Technical Data:
M.W. 447.51
Formula: C23H21N5O3S
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 850879-09-3
References:
Bearss DJ, et al. US Patent, US/2008/0226747. Hurley LH, et al. World Patent, WO/2005/037825. Mahadevan D, et al. Oncogene, 2007, 26(27), 3909-3919. Qi W, et al. BMC Cancer, 2009, 9, 142. Welsh JW, et al. Radiat Oncol, 2009, 4, 69. Zhao H, et al. Radiother Oncol, 2011, 101(1), 59-65.

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Tags: Inhibitors, Protein Tyrosine Kinase, c-Kit, Amuvatinib, 850879-09-3

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