TG101348

  • TG101348
Catalog No.: 3223

TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Phase 1/2.

Chemical Name:
N-tert-butyl-3-(5-methyl-2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)pyrimidin-4-ylamino)benzenesulfonamide

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Biological Activity:
TG-101348 (SAR302503) is a selective inhibitor of JAK2 with IC50 of 3 nM, 35- and 334-fold more selective for JAK2 versus JAK1 and JAK3. Phase 1/2.
Technical Data:
M.W. 524.68
Formula: C27H36N6O3S
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 936091-26-8
References:
Wernig G, et al. Cancer Cell, 2008, 13(4), 311-320. Geron I, et al. Cancer Cell, 2008, 13(4), 321-330. Lasho T, et al. Leukemia, 2010, 24(7), 1378-1380.

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Tags: Inhibitors, MStem Cells & Wnt JAK, TG101348, TG101348, 936091-26-8

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