ABT-737

Catalog No.: 3004

ABT-737 is a BH3 mimetic inhibitor of Bcl-xLBcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.

Chemical Name Benzamide, 4-[4-[(4'-chloro[1,1'-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]-

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Biological Activity:
ABT-737 is a BH3 mimetic inhibitor of Bcl-xL, Bcl-2 and Bcl-w with EC50 of 78.7 nM, 30.3 nM and 197.8 nM, respectively; no inhibition observed against Mcl-1, Bcl-B or Bfl-1. Phase 2.
Technical Data:
M.W. 813.43
Formula:

  C42H45ClN6O5S2

Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 852808-04-9
References:
Konopleva M, et al. Cancer Cell, 2006, 10(5), 375-388. van Delft MF,et al. Cancer Cell, 2006, 10(5), 389-399. Del Gaizo Moore V, et al. J Clin Invest, 2007, 117(1), 112-121. Tahir SK, et al. Cancer Res, 2007, 67(3), 1176-1183. Ishitsuka K, et al. Cancer Lett, 2012, 317(2), 218-225. Konopleva M, et al. Cancer Res, 2008, 68(9), 3413-3420. Wade M, et al. Cell Cycle, 2008, 7(13), 1973-1982. Paoluzzi L, et al. Blood, 2008, 112(7), 2906-2916. Li R, et al. Mol Pharmacol, 2009, 75(5), 1231-1239.

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Tags: Inhibitors, Apoptosis, Bcl-2, ABT-737, 852808-04-9

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