Alisertib

  • Alisertib
Catalog No.: 3012

Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.

Chemical Name Benzoic acid, 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-

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Biological Activity:
Alisertib (MLN8237) is a selective Aurora A inhibitor with IC50 of 1.2 nM. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3.
Technical Data:
M.W. 518.92
Formula:

C27H20ClFN4O4

Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 1028486-01-2
References:
Manfredi MG, et al. Clin Cancer Res, 2011, 17(24), 7614-7624. G?rgün G, et al. Blood, 2010, 115(25), 5202-521 Sehdev V, et al. Mol Cancer Ther, 2012, 11(3), 763-774.

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Tags: Inhibitors, Cell Cycle, Aurora Kinase, Alisertib, 1028486-01-2

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