Topotecan HCl

  • Topotecan HCl
Catalog No.: 3206

Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.

Chemical Name:
1-[5-[(2,3-Dichlorophenyl)thio]-4-nitro-2-thienyl]ethanone
 

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Biological Activity:
Topotecan (NSC 609699) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM, respectively.
Technical Data:
M.W. 457.91
Formula: C23H23N3O5.HCl
Solubility: DMSO
Purity: 98%
Storage: -20℃
CAS No: 119413-54-6
References:
Caceres G, et al. Anticancer Drugs. 2003, 14(7), 569-574. Uckun FM, et al. Blood. 1995. 85(10), 2817-2828. Ciusani E, et al. J Neurooncol. 2005, 71(1), 19-25. McCluskey AG, et al. J Nucl Med. 2012, 53(7), 1146-1154. Romanelli S, et al. Cancer Chemother Pharmacol. 1998, 41(5), 385-390.

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Tags: Inhibitors, DNA Damage, Topoisomerase, Topotecan HCl, 119413-54-6

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