1-Naphthyl PP1

  • 1-Naphthyl PP1
Catalog No.: 9796

A selective inhibitor of v-Src and c-Fyn as well as c-Abl.

 

 

Chemical Name: 1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Biological Activity:
1-Naphthyl PP1 selectively inhibits c-Src family kinases v-Src and c-Fyn as well as c-Abl tyrosine kinase (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). 1-Naphthyl PP1 preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).
Technical Data:
M.W. 317.39
Formula: C19H19N5
Solubility: Soluble in DMSO (~20 mg/ml), chloroform, ethanol (~2 mg/ml), DMF (~30 mg/ml), and 1: 5 solution of DMF: PBS (pH 7.2) (~0.15 mg/ml)
Storage: Store at 4° C
CAS No: 221243-82-9
References:
Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627. Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395.

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Tags: 1-Naphthyl PP1, supplier, Src, family, kinase, inhibits, inhibitors, c-Abl, v-Src, c-Fyn, 1-NaphthylPP1, 1NAPP1, 221243-82-9

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