Catalog No.: 9796
A selective inhibitor of v-Src and c-Fyn as well as c-Abl.
Chemical Name: 1-Tert-butyl-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
|1-Naphthyl PP1 selectively inhibits c-Src family kinases v-Src and c-Fyn as well as c-Abl tyrosine kinase (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). 1-Naphthyl PP1 preferentially inhibits mutant over wild-type kinases (IC50 values are 1.5 vs 1000 nM for I338G v-src and v-src respectively).|
|Solubility:||Soluble in DMSO (~20 mg/ml), chloroform, ethanol (~2 mg/ml), DMF (~30 mg/ml), and 1: 5 solution of DMF: PBS (pH 7.2) (~0.15 mg/ml)|
|Storage:||Store at 4° C|
|Bishop et al (1999) Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J.Am.Chem.Soc. 121 627. Bishop et al (2000) A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407 395.|
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